Author

Malcolm E. Cook

Stowers Institute for Medical ResearchORCID 0000-0002-2825-9183Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Abhinav SuriD· 1 shared Alex T. Von SchulzeiD· 1 shared Allison R. ScottiD· 1 shared Dai TsuchiyaiD· 1 shared Elizabeth Ellis· 1 shared Jacob Jensen· 1 shared Jay R. UnruhiD· 1 shared Jeffrey A. FarrelliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperDevelopmental Biology

Abhinav SurORCID

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Author profile →

2 papers

Recent·Most cited

Nascent protein retention at polysomes reduces kinetic barriers to self-assembly

Shriram Venkatesan, Alex T. Von Schulze, Jeffrey J. Lange, Jacob Jensen, Lexie E. Berkowicz, Dai Tsuchiya, Ning Zhang, Jennifer Gardner, Scott McCroskey, Ying Zhang, Selene K. Swanson, Yan Hao, Malcolm E. Cook, Tong Shu, Liam J. Holt, , Randal Halfmann

The paper shows that increasing translation initiation rates accelerates nucleation of aggregating proteins at polysomes, suggesting cotranslational nucleation influences proteome evolution.

bioRxiv · May 19, 2026 · PreprintCell Biology

prdm1a drives a fate switch between hair cells of different mechanosensory organs

Jeremy E. Sandler, Ya-Yin Tsai, Shiyuan Chen, Logan Sabin, Mark E. Lush, Abhinav Sur, Elizabeth Ellis, Nhung T. T. Tran, Malcolm E. Cook, Allison R. Scott, Jonathan S. Kniss, Jeffrey A. Farrell, Tatjana Piotrowski

This study shows prdm1a drives a fate switch between zebrafish lateral line and ear hair cells, altering morphology and transcriptome.

Nature Communications · Aug 18, 2025Peer-reviewedDevelopmental Biology