Jeffrey J. Lange

Fission yeast Fss1, a PQ-loop membrane protein, acts in diploids to build full-thickness, chitin-containing spore walls and within spores to maintain vacuole morphology and timely germination.

This study identifies a horizontal transfer of a bacterial TIR immune protein to amoebae, showing how it was domesticated into eukaryotic physiology through functional adaptation.

The paper shows that increasing translation initiation rates accelerates nucleation of aggregating proteins at polysomes, suggesting cotranslational nucleation influences proteome evolution.

The paper investigates how pericentromeric repeat copy number affects chromosome segregation and gene expression in fission yeast by analyzing natural variation and engineered strains.

This study shows TDP-43 amyloid forms only when its C-terminal domain arrests in soluble clusters, and this process can be inhibited by co-expressing an oligomeric binder.

This study examines how stress and aging affect spore health in Schizosaccharomyces pombe, identifying declines in germination, asymmetry, and stress tolerance.

This study shows common AAV vectors transduce multiple human brain cell types in organotypic slices, with astrocytes showing the most protein expression, and introduces a pipeline for optimizing AAV vectors.

This study investigates the molecular mechanisms of wtf killer meiotic drivers in fission yeasts, identifying factors that constrain toxicity and neutralization, and suggests potential roles in infertility.

This paper introduces a tunable amyloid-based fusion tag that allows precise control of protein concentration thresholds in cells.

The paper investigates how shared retinoic acid response elements regulate nascent transcription of Hoxb genes in mouse neural tube development using smFISH.

The paper shows that rRNA transcription by Pol I is essential for nucleolar structure and liquid-liquid phase separation in mouse embryos.

The paper shows that Lola-I, a Drosophila zinc finger transcription factor, regulates promoter accessibility and paused Pol II during development, similar to enhancer regulation by pioneer factors.

This study identifies Hox gene functions in adult tissue segmentation and asexual reproduction in planarians, showing distinct roles for hox3 and post2b.

The paper investigates how wtf4 meiotic drivers in S. pombe use dual transcriptional regulation and selective protein exclusion to ensure their transmission through gametes.

This paper identifies 532 genes involved in sexual reproduction in fission yeast using transposon-insertion sequencing, including 200 previously uncharacterized genes with vertebrate orthologs.

The paper introduces SCAP, a method combining affinity purification, live cell imaging, and cross-linking mass spectrometry to build integrative structural models of protein complexes.

The paper functionally characterizes 22 additional wtf genes in S. pombe, identifying eight new meiotic drivers and three new suppressors, showing high gamete-killing efficiency despite sequence divergence.