Pina Colarusso

Pathogenic Mitofusin 2 variants causing myopathy drive endosomal mtDNA release and inflammation

The paper identifies how pathogenic MFN2 variants cause mtDNA release into endosomes and mitochondrial-derived vesicles, triggering inflammation and myopathy, and suggests a therapeutic strategy using integrated stress response activation.

Mycobacterium avium subspecies paratuberculosis targets M cells in enteroid-derived monolayers through interactions with β1 integrins

This study identifies M cells as the primary target of Mycobacterium avium subspecies paratuberculosis (MAP) entry into the small intestinal epithelium, mediated by fibronectin-bridging interactions with β1 integrins.

Redox Signaling Mediates Differentiation of Adipose Progenitors in Response to Inflammatory Cytokines in the Adipose Tissue Secretome

This study identifies redox signaling and IL-6 as key regulators of adipogenesis in adipose progenitor cells under obesogenic conditions.

The majority of axonal mitochondria in mammalian neuronslack mitochondrial DNA and do not produce ATP

The paper shows that most axonal mitochondria in mammalian neurons lack mtDNA and do not produce ATP, contrasting with dendritic mitochondria.

Potentiation of Adipogenesis by Reactive Oxygen Species is a Unifying Mechanism in the Pro-adipogenic Properties of Bisphenol A and its New Structural Analogues.

This study shows that reactive oxygen species (ROS) mediate the pro-adipogenic effects of bisphenol A and its analogues by enhancing adipogenesis through mitochondrial ROS production.