A One-Shot Multivalent Live-Attenuated Candidate Influenza Vaccine against Divergent Zoonotic H5N1 Clades
Ahmed M. Elsayed, Ramya S. Barre, Arash Rahmani, Ruby A. Escobedo, Trushar Jeevan, Himadri Nath, Esteban M. Castro, Vinay Shivanna, Aitor Nogales, James Kobie, Richard J. Webby, Elsayed M. Abdelwhab, Adolfo García‐Sastre, Luis Martínez‐Sobrido
This paper develops a multivalent live-attenuated influenza vaccine that provides broad protection against multiple H5N1 clades by incorporating HA and NA from representative clades, showing robust immune responses and protection in mice.
bioRxiv · Aug 3, 2026 · PreprintMicrobiology