Richard J. Webby

This study characterizes the structural evolution of Fcα/μR-mediated antibody recognition across vertebrates by analyzing duck and mouse Fc/R interactions with IgM and IgA.

This study shows H5N1 influenza virus can be transmitted vertically through placental and mammary routes in pregnant mice, causing developmental impairments in offspring.

This paper develops a multivalent live-attenuated influenza vaccine that provides broad protection against multiple H5N1 clades by incorporating HA and NA from representative clades, showing robust immune responses and protection in mice.

Omni2Tree directly analyzes raw sequencing reads to reconstruct viral phylogenies and identify diversification, outperforming assembly and reference-based methods in low-coverage scenarios.

This study shows that influenza D virus efficiently replicates in human airway cells and tissues, evades innate immune responses, and may pose a zoonotic threat.

This study characterizes antibody responses to H3 influenza A virus in mallard ducks, revealing unique features compared to human antibodies and highlighting gene conversion in antibody evolution.

This paper evaluates a low-dose inactivated split virus vaccine against H5N1 influenza, showing cross-protective immunity against multiple clades in a mouse model.

This study shows that HA deletions and substitutions in influenza B/Victoria viruses enhance replication and virulence, contributing to their evolutionary success and vaccine challenges.

This study shows that dairy cows infected with H5N1 virus develop durable immunity that protects against severe disease but not complete viral clearance, and provides some cross-protection against different strains.

RSVrecon is a bioinformatics pipeline that enhances RSV surveillance by automating genotyping and reporting clinically important mutations, providing user-friendly results for clinical researchers.

This study generates human monoclonal antibodies against H5N1 clade 2.3.4.4b HA, identifying four that neutralize the virus in vitro and show protective effects in mice.

TIRTL-seq provides a scalable, cost-effective method for paired TCR repertoire sequencing, enabling accurate identification of TCR chain pairings and clonotype dynamics in large cohorts.

The paper examines the receptor-binding specificity of a bovine HPAI H5N1 virus using multiple assays and finds it preferentially binds avian-type receptors.

The paper tracks the emergence and spread of a novel reassortant swine influenza virus in Denmark, highlighting its zoonotic potential and antigenic differences from human viruses.

This study shows that equine H3N8 vaccine induces broad protection against influenza in multiple animal models, including neutralizing antibodies against diverse viral strains.

This study uses deep mutational scanning to analyze H5 hemagglutinin mutations and their impact on pandemic risk factors in influenza viruses.

This study assesses the seroprevalence of influenza A and B viruses in goats and sheep, finding high antibody rates against avian H5, H7, and H9 subtypes, suggesting these animals may be novel hosts for pandemic influenza viruses.

This study identifies the expression of avian and human influenza A virus receptors in bovine mammary glands, suggesting cattle could act as a mixing vessel for novel IAV generation.

The paper shows that pre-existing immunity to specific influenza antigens biases post-infection antibody responses, altering their dynamics and breadth.