Francesco Traccis

Sex-specific effects of prenatal delta-9-tetrahydrocannabinol exposure on repetitive behavior and prefrontal cortex neuronal excitability in preadolescent rats

This study shows that prenatal THC exposure affects repetitive behavior and PFC neuronal excitability in male rats, with no change in dopamine transmission but altered gene expression and sex differences in Netrin-1.

Sleep deprivation impairs information processing via dysregulation of chloride homeostasis in the prefrontal cortex

This study shows sleep deprivation impairs information processing in the prefrontal cortex by disrupting chloride homeostasis through KCC2 reduction and BDNF-TrkB signaling, which can be mitigated by bumetanide or AP synthesis blockade.

Sex-specific maladaptive responses to acute stress upon in utero THC exposure are mediated by dopamine

This study investigates sex-specific effects of prenatal THC exposure on stress-induced dopamine dysfunction and sensorimotor gating in rats, showing a role for HPA axis and dopamine signaling.

Endocannabinoid-dependent persistent decrease of GABAergic transmission on dopaminergic neurons underlies gene-environment interaction-induced susceptibility to cocaine sensitization

The paper shows that a gene-environment interaction involving MAO A gene variants and early life stress increases vulnerability to cocaine sensitization through endocannabinoid-dependent changes in GABAergic transmission in dopamine neurons.

Prenatal THC does not affect female mesolimbic dopaminergic system in preadolescent rats

This study shows that prenatal THC exposure does not alter mesolimbic dopamine function or behavior in female rats, unlike males.