The paper investigates associations between oculomotor responses during an oddball task and CSF biomarkers in MCI patients, finding p-Tau levels correlate with reduced cognitive vergence and pupil differentiation.

Scientific Reports · Sep 25, 2026Peer-reviewedNeuroscience

Cognitive Vergence and Pupillary Responses as Functional Oculomotor Signatures to Differentiate AT(N) Biological Profiles

Ricardo Martínez‐Flores, Isabel Martín-Sobrino, Neus Falgàs, Oriol Grau‐Rivera, Marc Suárez‐Calvet, Carlos Cristi‐Montero, Agustín M. Ibáñez, Hans Supèr

This study uses cognitive vergence and pupillary responses during a visual oddball task to differentiate AT(N) biological profiles in MCI patients.

bioRxiv · Apr 15, 2026 · PreprintNeuroscience

Enhanced proteome profiling of human cerebrospinal fluid using a commercial plasma enrichment strategy

Eva Borràs, Federica Anastasi, Olga Pastor, Marc Suárez‐Calvet, Eduard Sabidó

This study evaluates a commercial plasma enrichment strategy for improving low-abundance protein detection in human CSF, showing enhanced identification and coverage with high reproducibility.

Journal of Proteomics · Nov 25, 2025Peer-reviewedMolecular Biology

Polygenic proxies of age-related plasma protein levels reveal TIMP2 role in cognitive performance

Federica Anastasi, Patricia Genius, Blanca Rodríguez‐Fernández, Chengran Yang, Priyanka Gorijala, Jigyasha Timsina, Luis Felipe Hernández‐Villamizar, Luigi Lorenzini, Marta del Campo, Gonzalo Sánchez‐Benavides, Carolina Minguillón, Arcadi Navarro, Carlos Cruchaga, Marc Suárez‐Calvet, Natàlia Vilor‐Tejedor

The paper identifies TIMP2 as a blood protein associated with improved cognitive performance in humans using polygenic scores derived from protein quantitative trait loci data.

medRxiv · Jul 23, 2024 · PreprintGenetic & Genomic Medicine

Genetic characterization of the ALFA study: Uncovering genetic profiles in the Alzheimer's continuum.

Natàlia Vilor‐Tejedor, Patricia Genius, Blanca Rodríguez‐Fernández, Carolina Minguillón, Iman Sadeghi, Armand González‐Escalante, Marta Crous‐Bou, Marc Suárez‐Calvet, Oriol Grau‐Rivera, Anna Brugulat‐Serrat, Gonzalo Sánchez‐Benavides, Manel Esteller, Karine Fauria, José Luís Molinuevo, Arcadi Navarro, , for the ALFA study

The paper characterizes the genetic profiles of ALFA participants, showing high AD genetic risk and similarity to clinical groups along the AD continuum.

Alzheimer s & Dementia · Dec 13, 2023Peer-reviewedGenetic & Genomic Medicine

Leveraging large multi-center cohorts of Alzheimer Disease endophenotypes to understand the role of Klotho heterozygosity on disease risk

Muhammad Ali, Yun Ju Sung, Fengxian Wang, María Victoria Fernández, John C. Morris, Anne M. Fagan, Kaj Blennow, Henrik Zetterberg, Amanda Heslegrave, Per Johansson, Johan Svensson, Bengt Nellgård, Alberto Lleó, Daniel Andres Alcolea, Jordi Clarimón, , Carlos Cruchaga

This study investigates the association between Klotho heterozygosity and Alzheimer's disease risk in APOE4 carriers using multiple AD endophenotypes from large cohorts.

PLoS ONE · May 26, 2022Peer-reviewedGenetic & Genomic Medicine

The MS4A gene cluster is a key regulator of soluble TREM2 and Alzheimer disease risk

Yuetiva K. Deming, Fabia Filipello, Francesca Cignarella, Claudia Cantoni, Simon Hsu, Robert J. Mikesell, Zeran Li, Jorge L. Del‐Aguila, Umber Dube, Fabiana Geraldo Farias, Joseph L. Bradley, Bruno Benitez, John Budde, Laura Ibañez, Maria Victoria Fernandez, , Carlos Cruchaga

This study identifies genetic variants in the MS4A gene cluster associated with higher sTREM2 levels and reduced Alzheimer disease risk, suggesting MS4A4A regulates sTREM2 and contributes to AD pathogenesis.

Science Translational Medicine · Aug 14, 2019Peer-reviewedGenomics