Author

Hong Lin

St. Jude Children's Research HospitalORCID 0000-0002-3048-8233Unclaimed ORCID profile · follow to get notified of new preprints

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Hong Lin3 papers · University of Iowa

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Paul A. NorthcottiD· 2 shared Annarita PatriziiD· 1 shared Brian B. LiauiD· 1 shared Ceejay LeeiD· 1 shared Chiara Lukasch· 1 shared Eunju NamiD· 1 shared Frederik ArnskötteriD· 1 shared Haibin MaoiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

Paul A. NorthcottORCID

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2 papers

Recent·Most cited

KBTBD4 Cancer Hotspot Mutations Drive Neomorphic Degradation of HDAC1/2 Corepressor Complexes

Xiaowen Xie, Olivia Zhang, Megan J. R. Yeo, Ceejay Lee, Ran Tao, Stefan Andrew Harry, N. Connor Payne, Eunju Nam, Leena Paul, Yiran Li, Hui Si Kwok, Hanjie Jiang, Haibin Mao, Jennifer L. Hadley, Hong Lin, , Brian B. Liau

This study identifies how KBTBD4 cancer mutations drive neomorphic interactions with HDAC1/2, leading to CoREST degradation and tumor growth, and shows potential therapeutic strategies.

Nature · Feb 12, 2025Peer-reviewedMolecular Biology

Loss of the Familial Dysautonomia gene Elp1 in cerebellar granule cell progenitors leads to ataxia in mice

Frederik Arnskötter, Patricia Benites Goncalves da Silva, Mackenna E. Schouw, Chiara Lukasch, Luca Bianchini, Laura Sieber, Jesús García-López, Shiekh Tanveer Ahmad, Yiran Li, Hong Lin, Piyush K. Joshi, Lisa Spänig, Magdalena Radoš, Mykola Roiuk, Mari Sepp, , Lena M. Kutscher

This study shows that loss of Elp1 in cerebellar granule cell progenitors causes ataxia and cerebellar defects in mice, suggesting a role for ELP1 in FD pathogenesis.

Neurobiology of Disease · Jul 10, 2024Peer-reviewedNeuroscience