Author

Laura Sieber

German Cancer Research Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Lena M. KutscheriD· 3 shared Marc ZuckermanniD· 3 shared Patricia Benites Goncalves da SilvaiD· 3 shared Frederik ArnskötteriD· 2 shared Jana Nolle· 2 shared Lisa SpänigiD· 2 shared Luca BianchiniiD· 2 shared Mari SeppiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersDevelopmental Biology

Lena M. KutscherORCID

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3 papers

Recent·Most cited

Conserved cerebellar rhombic lip compartmentalization and Eomes regulatory networks govern unipolar brush cell development

Vuslat Akcay, Lisa Spänig, Wouter-Michiel A.M. Vierdag, Piyush Joshi, Patricia Benites Goncalves da Silva, Angelina Sanderson, Robert Reinhardt, Laura Sieber, Nina Hofmann, Jana Nolle, Franziska Schelb, Marc Zuckermann, Henrik Kaessmann, Stefan Michael Pfister, Adriana Sánchez‐Danés, , Lena M. Kutscher

This study shows that Eomes regulates UBC differentiation and migration in mice, mirroring human UBC development, and highlights conserved molecular mechanisms in cerebellar development.

bioRxiv · Jul 28, 2026 · PreprintDevelopmental Biology

Developmental determinants of male bias in medulloblastoma

Luca Bianchini, Ruijie Xu, David Filipovic, Patricia Benites Goncalves da Silva, Laura Sieber, Vuslat Akcay, Frederik Arnskötter, Piyush Joshi, Jana Nolle, Taha Soliman, Ran Tao, Alexandra Scheuing, Konstantin Okonechnikov, Alexander Atamian, Marc Zuckermann, , Lena M. Kutscher

The paper investigates sex bias in medulloblastoma by analyzing multi-omics data and mouse models, finding that testosterone drives male predominance in this tumor.

bioRxiv · Mar 25, 2026 · PreprintDevelopmental Biology

Loss of the Familial Dysautonomia gene Elp1 in cerebellar granule cell progenitors leads to ataxia in mice

Frederik Arnskötter, Patricia Benites Goncalves da Silva, Mackenna E. Schouw, Chiara Lukasch, Luca Bianchini, Laura Sieber, Jesús García-López, Shiekh Tanveer Ahmad, Yiran Li, Hong Lin, Piyush K. Joshi, Lisa Spänig, Magdalena Radoš, Mykola Roiuk, Mari Sepp, , Lena M. Kutscher

This study shows that loss of Elp1 in cerebellar granule cell progenitors causes ataxia and cerebellar defects in mice, suggesting a role for ELP1 in FD pathogenesis.

Neurobiology of Disease · Jul 10, 2024Peer-reviewedNeuroscience