Juha O. Rinne

The paper investigates diurnal and seasonal variations in brain mu-opioid and dopamine D2 receptor signaling in humans using PET data and finds MOR availability increases in the afternoon, with seasonal and trait-anxiety influences.

This study identifies 1,242 novel genetic variants and 31 novel genes associated with frailty through genome-wide association and proteomics integration.

This study conducts a genome-wide meta-analysis across three biobanks to identify new genetic loci associated with lumbar disc herniation, expanding the known genetic landscape.

This study shows that the PLCgamma2-P522R variant reduces beta-amyloid pathology and enhances microglial function in AD models, suggesting an anti-ageing mechanism.

The paper investigates seasonal variation in D2/3 dopamine receptor availability in the human brain using PET scans and finds a negative correlation between daylength and receptor availability in the striatum.

The paper examines the effect of APOE ε4 gene dose on glial reactivity and β-amyloid pathology in cognitively unimpaired individuals using PET, MRI, and plasma biomarkers.

This study examines age and sex differences in striatal D2R availability using a large PET cohort, finding age-related decline and sex differences in D2R levels.

This study finds seasonal variation in brain mu-opioid receptor availability in humans, showing an inverted U-shaped relationship with daylength.

The paper introduces a multivariate GWAS framework that identifies functional variants and disease associations by transforming multivariate results into univariate phenotypes for follow-up analysis.

Magia automates PET brain data processing, producing outcome measures consistent with manual methods despite anatomical differences in reference regions.

The paper identifies DNA methylation differences in peripheral blood of Alzheimer’s disease discordant twin pairs, linking these to brain gene expression and neuronal functions.