Author

Daniel C. Factor

Case Western Reserve UniversityORCID 0000-0002-3200-7560Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew R. MortoniD· 1 shared Benjamin L.L. ClaytoniD· 1 shared Charles Y. LiniD· 1 shared Hannah E. OlseniD· 1 shared Jonathan E. HenningeriD· 1 shared Jošt Vrabič KoreniD· 1 shared Kevin Cameron AllaniD· 1 shared Lucille R. Hu· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperDevelopmental Biology

Andrew R. MortonORCID

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1 paper

Recent·Most cited

Cellular Maturation of Oligodendrocytes is Governed by Transient Gene Melting

Kevin Cameron Allan, Tyler E. Miller, Andrew R. Morton, Marissa A. Scavuzzo, Matthew S. Elitt, Benjamin L.L. Clayton, Lucille R. Hu, Jošt Vrabič Koren, Hannah E. Olsen, Daniel C. Factor, Jonathan E. Henninger, Richard A. Young, Charles Y. Lin, Peter C. Scacheri, Paul J. Tesar

This study identifies a transcriptional mechanism that controls oligodendrocyte maturation through SOX6-mediated gene melting, showing that suppressing SOX6 accelerates maturation and that an immature SOX6 signature is enriched in multiple sclerosis patient brains.

bioRxiv · Nov 17, 2022 · PreprintDevelopmental Biology