MicrobiologyJournal of VirologyPeer-reviewed
The ORF6 accessory protein contributes to SARS-CoV-2 virulence and pathogenicity in the naturally susceptible feline model of infection
Mohammed Nooruzzaman, Salman Latif Butt, Ruchi Rani…·Diego G. Diel
This study shows that deleting ORF6 from SARS-CoV-2 reduces virulence and pathogenicity in cats, with decreased immune suppression and reduced viral replication.
DOI 10.1128/jvi.00644-25