Targeting SUV4-20H epigenetic enzymes as therapeutic strategy for enhancing topoisomerase II poisoning in prostate cancer
Fatima Alhourani, Marine Tauziet, Julie Patouillard, Benoît Miotto, Véronique Baldin, Aurélie Gennetier, Simon George, Xavier Mialhe, Cyril Ribeyre, Philippe Pourquier, Florence M. Cammas, Adeline Torro, Diégo Tosi, Céline Gongora, Mona Dergham, , Eric Julien
This study shows that inhibiting SUV4-20H enzymes enhances the effectiveness of TOP2 poisons in prostate cancer by increasing DNA damage and impairing repair mechanisms.
bioRxiv · Mar 11, 2025 · PreprintCancer Biology