This paper develops DrugSeq, a computational platform that predicts drug sensitivities in medulloblastoma subgroups, identifying subgroup-specific therapies and potential drug repositioning candidates.

Scientific Reports · Nov 27, 2025Peer-reviewedCancer Biology

OpenPBTA: An Open Pediatric Brain Tumor Atlas

Joshua A. Shapiro, Krutika Satish Gaonkar, Stephanie J. Spielman, Candace Savonen, Chanté J. Bethell, Run Jin, Komal S. Rathi, Yuankun Zhu, Laura E. Egolf, Bailey Farrow, Daniel P. Miller, Yang Yang, Tejaswi Koganti, Nighat Noureen, Mateusz Koptyra, , Jaclyn Taroni

OpenPBTA provides a collaborative platform to genomically characterize 1,074 pediatric brain tumors and 22 cell lines, offering analysis modules and somatic datasets for research and clinical applications.

Cell Genomics · May 31, 2023Peer-reviewedGenomics

Copy number heterogeneity, large origin tandem repeats, and interspecies recombination in HHV-6A and HHV-6B reference strains

Alexander L. Greninger, Pavitra Roychoudhury, Negar Makhsous, Derek J. Hanson, Jill Chase, G. R. F. Krueger, Hong Jian Xie, Meei-Li W. Huang, Lindsay M. Saunders, Dharam V. Ablashi, David M. Koelle, Linda Cook, Keith R. Jerome

The paper uses next-generation sequencing to analyze copy number variations and interspecies recombination in HHV-6A and HHV-6B reference strains, revealing large tandem repeats and a novel recombinant strain.

Journal of Virology · Feb 27, 2018Peer-reviewedGenomics