Seipin mediates Perilipin-1 recruitment to lipid droplets to preserve human adipocyte identity
Denise Zhong, Ioanna Stavrakaki, Anand Desai, Tiffany DeSouza, Sabine Linskey, Shannon Joyce, Courtney L. Hatton, Danna Garcia, Reyan Kassam, Gregory M. Hendricks, Keith R. Reddig, Guangping Gao, Jun Xie, Maria Paz Gonzalez-Perez, Andre F. C. Vieira, , Silvia Corvera
This study shows seipin is essential for recruiting Perilipin-1 to lipid droplets in human adipocytes, maintaining adipocyte identity and preventing de-differentiation.
bioRxiv · Nov 9, 2025 · PreprintCell Biology