Author

Lena Sophie Tittel

Johannes Gutenberg University MainzORCID 0000-0002-3394-0643Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Assay:proteomics· 2 Organism:C. elegans· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Assay:long-read sequencing· 1 Research Focus:protein design· 1

Frequent Co-Authors

Alina-Andrea KraftiD· 2 shared Kaushik Viswanathan IyeriD· 2 shared Marie‐Luise WinziD· 2 shared Max MülleriD· 2 shared Bettina WarscheidiD· 1 shared Chloé Astrid WalteriD· 1 shared Ekkehard SchulzeiD· 1 shared Elisabeth PetfalskiiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersMolecular Biology

Alina-Andrea KraftORCID

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3 papers

Recent·Most cited

Yeast elongation factor homolog New1 protects a subset of mRNAs from degradation by no-go decay

Max Müller, Lena Sophie Tittel, Elisabeth Petfalski, Kaushik Viswanathan Iyer, Alina-Andrea Kraft, Stefan Pastore, Tamer Butto, Marie‐Luise Winz

The paper shows that New1 prevents ribosomal collisions and subsequent mRNA degradation in yeast by no-go decay, protecting essential genes from downregulation.

Nucleic Acids Research · Jan 14, 2026Peer-reviewedMolecular Biology

Jlp2 is a non-canonical release factor that protects cells during ribosome stalling

Kaushik Viswanathan Iyer, Alina-Andrea Kraft, Chloé Astrid Walter, Max Müller, Lena Sophie Tittel, Grit Florentine Stampa, Marie‐Luise Winz

This study identifies Jlp2 as a non-canonical release factor that facilitates peptide release from tRNA and prevents excessive CAT tailing during ribosome stalling.

bioRxiv · Sep 4, 2025 · PreprintMolecular Biology

Pseudokinase HPO-11 inhibits nonsense-mediated decay to ensure genome stability in C. elegans

Qian Zhao, Erika Donner von Gromoff, Wei Yang, Jennifer Schwarz, Lena Sophie Tittel, Ekkehard Schulze, Bettina Warscheid, Ralf Baumeister, Wenjing Qi

This study identifies HPO-11 as a pseudokinase that inhibits nonsense-mediated decay (NMD) to maintain genome stability in C. elegans by preventing R-loop accumulation and DNA damage.

bioRxiv · Sep 4, 2022 · PreprintMolecular Biology