Ralf Baumeister

Targeting the paralog protein for degradation accounts for the opposite roles of NRBP1 and NRBP2 in regulating LINE1 retrotransposition

The paper shows NRBP1 and NRBP2 oppositely regulate LINE1 retrotransposition through proteasome-mediated degradation of NRBP1 by NRBP2, with NRBP2's regulatory function evolving later.

Pseudokinase HPO-11 inhibits nonsense-mediated decay to ensure genome stability in C. elegans

This study identifies HPO-11 as a pseudokinase that inhibits nonsense-mediated decay (NMD) to maintain genome stability in C. elegans by preventing R-loop accumulation and DNA damage.

A secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans

This study identifies ENDU-2, a secreted RNase in C. elegans, that maintains germline immortality by regulating mRNA abundance and preventing soma-specific gene misexpression in the germline.

Combined flow cytometry and high throughput image analysis for the study of essential genes in Caenorhabditis elegans

The paper develops a method to analyze essential genes in C. elegans by combining flow cytometry and high-throughput image analysis to sort and study homozygous lethal mutants.