Author

Rafael A. Cubas

GenentechORCID 0000-0002-3450-9054Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Sören MülleriD· 2 shared Alessandra CastiglioniiD· 1 shared Caroline WhittyiD· 1 shared Cecilia ChiuiD· 1 shared Dean SheppardiD· 1 shared George CoukosiD· 1 shared Helena PaïdassiiD· 1 shared Hsiao‐Yen MaiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Sören MüllerORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Inhibition of integrin αvβ8-mediated TGFβ activation and active-TGFβ blockade promote anti-tumor immunity through distinct biological mechanisms

Kate Williams, Stephanie Mittman, Natalie S. Firmino, Jasmine W. Larrick, Zhe Zhang, Caroline Whitty, Hsiao‐Yen Ma, Xin Ren, Cecilia Chiu, Yagai Yang, Jianhuan Zhang, Minh Thai, Helena Païdassi, Matthieu Masureel, Kelly M. Loyet, , Alessandra Castiglioni

The paper shows that blocking integrin αvβ8 suppresses TGFβ in tumor-draining lymph nodes and enhances DC-T cell activation, offering a new immunotherapy strategy distinct from TGFβ ligand blockade.

bioRxiv · Jul 9, 2026 · PreprintImmunology

Projecting single-cell transcriptomics data onto a reference T cell atlas to interpret immune responses

Massimo Andreatta, Jesús Corría-Osorio, Sören Müller, Rafael A. Cubas, George Coukos, Santiago J. Carmona

The paper introduces ProjecTILs, a method to project scRNA-seq data onto T cell reference atlases to interpret immune responses and perturbations.

Nature Communications · May 20, 2021Peer-reviewedBioinformatics