Author

Hyun-Kyung Chang

Columbia University Irving Medical CenterORCID 0000-0002-3490-7597Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Genetics· 2 Genomics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Adam D. HudginsiD· 2 shared Di GuaniD· 2 shared Jiping YangiD· 2 shared Xizhe Wang· 2 shared Yizhou ZhuiD· 2 shared Yousin SuhiD· 2 shared Allen Y. ChungiD· 1 shared Archana Tare· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenetics

Adam D. HudginsORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Identification of functional non-coding variants affecting Alzheimer's disease risk by Massively Parallel Reporter Assay

Adam D. Hudgins, Hyun-Kyung Chang, Seung-Soo Kim, Jiping Yang, Di Guan, Xizhe Wang, Yizhou Zhu, Yousin Suh

The paper identifies functional non-coding variants affecting Alzheimer's disease risk using MPRA and validates their effects through CRISPR/Cas9.

bioRxiv · May 5, 2026 · PreprintGenetics

Single-Cell RNA-Seq Reveals Adventitial Fibroblast Alterations during Mouse Atherosclerosis

Lauren E. Fries, Allen Y. Chung, Hyun-Kyung Chang, Timothy L. Yuan, Robert C. Bauer

The paper uses scRNA-seq to study adventitial fibroblast changes in mouse atherosclerosis and identifies SERPINH1 as a key regulator affecting fibroblast function.

Atherosclerosis · Oct 3, 2025Peer-reviewedGenomics

Longevity-associated SMAD3 non-coding centenarian variant impairs a cell-type specific enhancer to reduce inflammation

Jiping Yang, Archana Tare, Lei Justan Zhang, Seungsoo Kim, Seungjin Ryu, Qinghua Guo, Yizhou Zhu, Xizhe Wang, Xifan Wang, Adam D. Hudgins, Di Guan, Chen Jin, Hyun‐Kyung Chang, Gil Atzmon, Sofiya Milman, , Yousin Suh

The paper identifies a longevity-associated SMAD3 non-coding variant that impairs a cell-type specific enhancer, reducing inflammation and senescence in endothelial cells and improving healthspan in a mouse model.

bioRxiv · May 17, 2023 · PreprintGenetics