Xizhe Wang

Identification of functional non-coding variants affecting Alzheimer's disease risk by Massively Parallel Reporter Assay

The paper identifies functional non-coding variants affecting Alzheimer's disease risk using MPRA and validates their effects through CRISPR/Cas9.

Transcriptomic signatures of mouse ovarian aging and estropausal transition at single cell resolution

This study uses single-cell transcriptomics to analyze mouse ovarian aging and identifies molecular changes associated with the estropausal transition.

In vitro heterochronic parabiosis identifies pigment epithelium-derived factor as a systemic mediator of rejuvenation by young blood

This study identifies PEDF as a systemic factor in young blood that rejuvenates cells and tissues, using an in vitro heterochronic parabiosis system.

The regulation of Insulin/IGF-1 signaling by miR-142-3p associated with human longevity

This study identifies miR-142-3p as a regulator of human longevity by modulating the insulin/IGF-1 signaling pathway in B-cells and mice.

Longevity-associated SMAD3 non-coding centenarian variant impairs a cell-type specific enhancer to reduce inflammation

The paper identifies a longevity-associated SMAD3 non-coding variant that impairs a cell-type specific enhancer, reducing inflammation and senescence in endothelial cells and improving healthspan in a mouse model.

The regulatory landscapes of human ovarian ageing

This study uses single-nuclei multi-omics analysis to identify molecular and cellular changes in human ovarian ageing and links genetic variants to age at natural menopause.