An essential role for dNTP homeostasis following CDK-induced replication stress
Chen‐Chun Pai, Kuo‐Feng Hsu, Samuel C. Durley, Andrea Keszthelyi, Stephen E. Kearsey, Charalampos Rallis, Lisa K. Folkes, Rachel S. Deegan, Sarah E. Wilkins, Sophia X. Pfister, Nagore de León, Christopher John Schofield, Jürg Bähler, Antony M. Carr, Timothy C. Humphrey
The paper shows that disrupting dNTP homeostasis is synthetically lethal with CDK-induced replication stress in fission yeast, leading to genome instability and cell death.
Journal of Cell Science · Jan 23, 2019Peer-reviewedMolecular Biology