Roberto Giambruno

The RNA-binding activity of SACSIN HEPN domain is connected to ARSACS

This study identifies RNA-binding activity of the SACSIN HEPN domain as linked to ARSACS, providing insights into its molecular function and potential therapeutic targets.

Discovering host protein interactions specific for SARS-CoV-2 RNA genome

The paper identifies host proteins interacting with SARS-CoV-2 RNA ends, highlighting pseudouridine synthase PUS7 and post-transcriptional modifications in viral RNA structure and function.

ProMetheusDB: an in-depth analysis of the high-quality human methyl-proteome

The paper presents a high-quality human methyl-proteome dataset generated using hmSILAC and a machine learning tool, showing improved identification of methyl-peptides and novel histone methylation marks.

Nanopore ReCappable Sequencing maps SARS-CoV-2 5' capping sites and provides new insights into the structure of sgRNAs

This study introduces NRCeq, a method to identify capped full-length SARS-CoV-2 transcripts, revealing new insights into sgRNA structure and expression.

PRMT1-mediated methylation of the Large Drosha Complex regulates microRNA biogenesis

This study identifies PRMT1-mediated methylation of the Large Drosha Complex as critical for miRNA biogenesis by regulating pri-to-pre-miRNA processing.