Feiyue Cheng

Nucleoid-associated proteins sense phage-induced genome damage to elicit abortive infection

This study identifies a novel bacterial defense mechanism where nucleoid-associated proteins detect phage-induced genome damage by relocating to the cytoplasm and activating immune effectors.

CRISPR-Cas supervises diverse anti-phage defense systems

This study shows CRISPR-Cas regulates diverse anti-phage systems via crlRNAs, balancing their expression to prevent autoimmunity and enhance anti-phage defense.

Phage CRISPR-like regulatory RNAs silence multilayered bacterial immune systems

The paper identifies viral crlRNAs that suppress bacterial immunity by reprogramming Cas proteins and demonstrates their potential for mammalian genome editing.