Karl‐Werner Schramm

Enduring Autism-like Phenotypes and Deregulated Hypothalamic Prosocial Peptides After Early-Life Exposure to Indoor Flame Retardants in Male C57BL/6 Mice

This study shows that early-life exposure to PBDEs in mice leads to autism-like behaviors and changes in prosocial neuropeptide expression.

Maternal Thyroid Supplementation Prevents Autistic-relevant Social Behavior and Hypothalamic Oxytocin Depletion Produced by Developmental Exposure to Environmental Toxicants

This study shows maternal thyroid supplementation prevents PBDE-induced social behavior deficits and hypothalamic oxytocin depletion in mice.

Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism

This study identifies FKBP51 as a molecular switch linking autophagy to metabolism in the mediobasal hypothalamus, showing its role in obesity regulation.

Persistent autism-relevant phenotype produced by in utero and lactational exposure of female mice to the commercial PBDE mixture, DE-71

This study shows that exposure to PBDE mixture DE-71 during pregnancy and lactation in female mice leads to autism-relevant behavioral and neurochemical changes in offspring.