Simone Roeh

Human neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression

This study shows glucocorticoids increase specific basal progenitors via ZBTB16, leading to more neurons and linking to educational attainment and brain structure.

DiffBrainNet: differential analyses add new insights into the response to glucocorticoids at the level of genes, networks and brain regions

The paper introduces DiffBrainNet, a framework combining differential expression and network analysis to study glucocorticoid responses in mouse brain regions, revealing gene-level and network-level insights.

Assessment of glucocorticoid-induced enhancer activity of eSNP regions using STARR-seq reveals novel molecular mechanisms in psychiatric disorders

The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus

This study investigates the role of Fkbp5 in the paraventricular nucleus of the hypothalamus in shaping the HPA axis stress response through genetic manipulations.

Hypothalamic glucocorticoid receptor in CRF neurons is essential for HPA axis habituation to repeated stressor

The paper shows that glucocorticoid receptors in CRF neurons are essential for HPA axis habituation to repeated stressors by modulating inhibitory tone and dampening activation.

Cell-type specific impact of glucocorticoid receptor activation on the developing brain

The paper investigates how glucocorticoid receptor activation affects neuronal development in fetal human brain organoids using single-cell transcriptomics, finding cell-type specific impacts on differentiation and behavior-related gene expression.

HAM-TBS: High accuracy methylation measurements via targeted bisulfite sequencing

HAM-TBS provides a high-accuracy, cost-effective method for measuring DNA methylation in specific genomic regions using targeted bisulfite sequencing.