Bertram Müller‐Myhsok

Epigenomic embedding of childhood adversity links to disease risk and chronic immune changes

The paper identifies contmeQTLs linking childhood adversity to epigenetic changes in immune cells, which are associated with disease risk and inflammatory profiles.

Loss of noradrenergic Fkbp5 disrupts social behavior and norepinephrine dynamics in the basolateral amygdala

This study shows that Fkbp5 in noradrenergic neurons affects social behavior and norepinephrine dynamics in the basolateral amygdala, specifically in male mice.

Multi-omic data integration and analyses for biomarker discovery of spontaneous preterm birth phenotypes

The paper integrates genomics, transcriptomics, and metabolomics data from preterm birth patients to identify molecular signatures associated with spontaneous preterm birth and PPROM.

netMUG: a novel network-guided multi-view clustering workflow for dissecting genetic and facial heterogeneity

netMUG identifies actionable subgroups using network-guided multi-view clustering, showing improved performance over existing methods in synthetic and real data.

Automatically annotated motion tracking identifies a distinct social behavioral profile following chronic social defeat stress

The paper introduces DeepOF, an open-source tool for analyzing social behavior in mice, and finds it detects distinct stress-induced social behavioral patterns.

Genetic structure of major depression symptoms across clinical and community cohorts

This study identifies genetic subtypes of major depressive symptoms by analyzing data from clinical and community cohorts, finding distinct factors for appetite/weight symptoms and missing data patterns.

Sex differences in the genetic regulation of the blood transcriptome response to glucocorticoid receptor activation

The paper identifies sex-specific genetic regulators of the blood transcriptome response to glucocorticoid receptor activation and links them to depression risk in a cohort of children and adolescents.

Genetic factors influencing a neurobiological substrate for psychiatric disorders

The paper investigates genetic factors influencing a neurobiological substrate for psychiatric disorders and finds that a common genetic variant is associated with the substrate but not directly with disease risk.

"The Heidelberg Five" Personality Dimensions: Genome-wide Associations, Polygenic Risk for Neuroticism, and Psychopathology 20 Years after Assessment

The paper identifies genetic associations with five personality dimensions and links them to psychiatric symptoms over time.

Genome-wide association study in European patients with congenital heart disease identifies risk loci for transposition of the great arteries and anomalies of the thoracic arteries and veins and expression of discovered candidate genes in the developing heart

This study identifies genetic risk loci for congenital heart disease subtypes and shows candidate genes play essential roles in heart development.

DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning

DeepWAS integrates regulatory effect predictions of variants into GWAS to identify regulatory SNPs associated with diseases and traits.

Minimal phenotyping yields GWAS hits of reduced specificity for major depression

This paper shows that GWAS using minimal phenotyping for depression identifies non-specific genetic factors shared with other psychiatric conditions, not specific to major depressive disorder.

Genetic variation in the Major Histocompatibility Complex and association with depression

This study investigates whether genetic variation in the Major Histocompatibility Complex (MHC) is associated with depression risk, finding no significant associations at a conservative threshold.

Genome Wide Association Scan identifies new variants associated with a cognitive predictor of dyslexia.

The paper conducts a GWAS to identify genetic variants associated with a cognitive predictor of dyslexia, finding significant associations with variants near MIR924HG and NKAIN3.

Cis-epistasis at the LPA locus and risk of coronary artery disease

The paper identifies cis-epistasis at the LPA locus involving two SNPs that interact to modulate coronary artery disease risk and related traits.

Epigenetic derepression of FKBP5 by aging and stress contributes to NF-kB-driven inflammation and cardiovascular risk

The paper identifies FKBP5 epigenetic derepression by aging and stress as a driver of NF-kB-driven inflammation and cardiovascular risk through in vitro and cohort studies.

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

This study conducts a trans-ancestral GWAS of alcohol dependence, identifying genetic variants and correlations with psychiatric disorders.

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

This paper conducts a GWAS on suicide attempt across psychiatric disorders, identifying genetic loci and showing polygenic risk for major depression predicts suicide attempt in multiple disorders.

Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations

The paper identifies response eQTLs that modify genetic regulation during immune activation and shows their enrichment in autoimmune disease GWAS signals.