Author

Justin A. Shyer

GenentechORCID 0000-0002-3685-9074Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Aimee Wu· 1 shared Akshay T. KrishnamurtyiD· 1 shared Alberto GuarnieriiD· 1 shared Alessandra CastiglioniiD· 1 shared Apple Cortez VollmersiD· 1 shared Autumn Gabrielle YorkiD· 1 shared Can CuiiD· 1 shared Christian Cox· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Aimee Wu

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Fibroblast TGF-β3 promotes tissue-residency and survival of CD8 T cells in barrier tissues and tumors

Sunny Z. Wu, Ryan S. Lane, Alessandra Castiglioni, Endi K. Santosa, Alberto Guarnieri, Apple Cortez Vollmers, Christian Cox, Yagai Yang, Hannah S. Bender, Tianhe Sun, Justin A. Shyer, Akshay T. Krishnamurty, Sören Müller, Shannon J. Turley

This study identifies fibroblast-derived TGF-β3 as a critical factor sustaining CD8+ TRM in barrier tissues and tumors, showing its role in survival and function.

bioRxiv · May 22, 2026 · PreprintImmunology

IL-4 Licenses B Cell Activation Through Cholesterol Synthesis

Holly R. Steach, Autumn Gabrielle York, Jonathan R. Mattingly, Mathias H. Skadow, Shuting Chen, Jun Zhao, Kevin J. Williams, Quan Zhou, Weu-Yuan Hsieh, J. Richard Brewer, Rihao Qu, Justin A. Shyer, Christian Harman, Esen Sefik, Walter K. Mowel, , Richard Anthony Flavell

This study shows IL-4 promotes B cell activation by upregulating cholesterol synthesis, which is essential for ER expansion, cell cycle progression, and proliferation during influenza infection.

bioRxiv · May 13, 2024 · PreprintImmunology