Author

Phuc Leo H. Vo

Columbia UniversityORCID 0000-0002-3719-7770Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:CRISPR screen· 2 Organism:bacteria (other)· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1 Research Focus:genome assembly· 1 Organism:human· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Samuel H. SternbergiD· 3 shared Christopher AcreeiD· 2 shared Sanne E. KlompeiD· 2 shared Alejandro ChaveziD· 1 shared Carlotta RondaiD· 1 shared Ethan E. CheniD· 1 shared George D. LampeiD· 1 shared Harris H. WangiD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersMolecular Biology

Samuel H. SternbergORCID

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3 papers

Recent·Most cited

GeneticsNature BiotechnologyPeer-reviewedMar 29, 2023

Targeted DNA integration in human cells without double-strand breaks using CRISPR RNA-guided transposases

George D. Lampe, Rebeca T. King, Tyler S. Halpin-Healy…·Samuel H. Sternberg

This paper develops a CRISPR-guided transposon system for DSB-free DNA integration in human cells, improving efficiency and reducing off-target effects.

146 citationstop 1%

humanCRISPR screen

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Molecular BiologyMobile DNAPeer-reviewedJun 8, 2021

Unbiased profiling of CRISPR RNA-guided transposition products by long-read sequencing

Phuc Leo H. Vo, Christopher Acree, Melissa Laird Smith, Samuel H. Sternberg

The paper uses long-read sequencing to analyze transposition products of RNA-guided transposons, finding they primarily use copy-and-paste mechanisms and report engineered variants with TnsAB fusion proteins.

52 citations

E. coliwhole-genome sequencing

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Molecular BiologyNature BiotechnologyPeer-reviewedNov 23, 2020

CRISPR RNA-guided integrases for high-efficiency and multiplexed bacterial genome engineering

Phuc Leo H. Vo, Carlotta Ronda, Sanne E. Klompe…·Samuel H. Sternberg

This paper introduces an improved CRISPR-based system for high-efficiency, multiplexed bacterial genome engineering using RNA-guided integrases.

346 citationstop 1%

bacteria (other)CRISPR screen

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