Discovery and chemical optimisation of a Potent, Bi-cyclic (Bicycle(R)) Antimicrobial Inhibitor of Escherichia coli PBP3
Catherine E Rowland, Hector Newman, Tazmin T. Martin, Rachel Dods, Nikolaos Bournakas, James M. Wagstaff, Nick Lewis, Steven J. Stanway, Matthew R. Balmforth, Celia Kessler, Katerine Van Rietschoten, Dom Bellini, David I. Roper, Adrian J. Lloyd, Christopher Gerard Dowson, , Michael J. Dawson
This study discovers and optimizes bicyclic peptide inhibitors of E. coli PBP3, showing high-affinity binding and broad-spectrum antimicrobial activity.
Communications Biology · May 28, 2025Peer-reviewedBiochemistry