Investigation of anti-SARS CoV-2 multimeric bicyclic peptide inhibitors in a range of pre-clinical therapeutic settings
Maximilian A. J. Harman, Katherine U. Gaynor, Guido Papa, Simone Pellegrino, G.A. Bezerra, Brian McGuinness, Phil Jeffrey, Paul Beswick, Steven J. Stanway, Katerine Van Rietschoten, Liuhong Chen, Ieva Drulyte, Joanne Herriott, Edyta Kijak, Eduardo Gallardo Toledo, , Michael J. Skynner
This paper evaluates the efficacy of multimeric bicyclic peptides as antiviral agents in preclinical SARS-CoV-2 models, showing significant reduction in viral burden across multiple therapeutic settings.
bioRxiv · Oct 3, 2025 · PreprintPharmacology & Toxicology