Author

Alex Mann

hVIVO (United Kingdom)ORCID 0000-0002-3744-4604Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Assay:flow cytometry· 1 Organism:mouse· 1

Frequent Co-Authors

Andrew P. CatchpoleiD· 2 shared Adlina Chan· 1 shared Alison Boyers· 1 shared Andreas Tiffeau-MayeriD· 1 shared Andrew G. T. PyoiD· 1 shared Anice C. LoweniD· 1 shared Ben KillingleyiD· 1 shared Benny ChainiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMicrobiology

Andrew P. CatchpoleORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Within-host adaptive evolution is limited by genetic drift in experimental human influenza A virus infections

Lucas M. Ferreri, Nahara Vargas-Maldonado, Valerie Le Sage, Christina Marcelo Leyson, Matthew D. Pauly, David VanInsberghe, Vedhika Raghunathan, Shamika Danzy, Hollie Macenczak, Jessica J. Traenkner, Flu CHIM Study Group, Andrew P. Catchpole, Alex Mann, Nadine Rouphael, Seema S. Lakdawala, , Anice C. Lowen

This study examines within-host evolutionary dynamics of influenza A virus in humans and ferrets, finding that genetic drift limits selection efficiency in humans but not in ferrets.

bioRxiv · Jan 7, 2026 · PreprintMicrobiology

Temporal Dynamics of Antigen-Specific T Cell Expansion in Primary SARS-CoV-2 Infection

Andrew G. T. Pyo, Adlina Chan, Joshua Rosenheim, Clare E Thakker, Lucy C. K. Bell, Gayathri Nageswaran, Suzanne Byrne, Ben Killingley, David Scobie, Mariya Kalinova, Alison Boyers, Andrew P. Catchpole, Alex Mann, Rik G.H. Lindeboom, Marko Nikolić, , Benny Chain

The paper quantifies T cell response dynamics during primary SARS-CoV-2 infection, showing clone-intrinsic properties drive clonal kinetics and providing insights for vaccine design.

bioRxiv · Nov 4, 2025 · PreprintBiophysics