Author

Philipp A. Greif

German Cancer Research CenterORCID 0000-0002-3744-7936Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2

Frequent Co-Authors

Bernhard KusteriD· 2 shared Binje VickiD· 2 shared Irmela JeremiasiD· 2 shared Leticia Fröhlich ArchangeloiD· 2 shared Sebastian VosbergiD· 2 shared Tobias HeroldiD· 2 shared Vanessa Cristina ArfelliiD· 2 shared Yun-Chien ChangiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

Bernhard KusterORCID

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Author profile →

4 papers

Recent·Most cited

Loss of PIMREG impairs double-strand break signaling and repair

Maria Vitoria de Rizzo Gasparini, Laís do Carmo, Giovanna Goncalves de Almeida, Mariana Siqueira Lacerda Mamede, Isabela David Cardoso, Lígia Arantes Sardinha, Isabela Spido Dias, Jennifer Ann Black, Vanessa Cristina Arfelli, Yun-Chien Chang, Elza Tiemi Sakamoto‐Hojo, Stephanie Heinzlmeir, Bernhard Kuster, Philipp A. Greif, Leticia Fröhlich Archangelo

This study investigates the role of PIMREG in DNA damage response in GBM cells, finding that its loss impairs double-strand break signaling and repair.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · Sep 29, 2026Peer-reviewedCancer Biology

A platform of robust patient-derived leukemia models covering subgroups for which no cell lines exist

Binje Vick, Vindi Jurinović, Kristina Kuhbandner, Lena Lagally, Lisa Latzko, Chiara Arnreich, Gerulf Hänel, Amelie Muth, Maja Rothenberg‐Thurley, Annika Maria Dufour, Stephanie E. Schneider, Lesca Miriam Holdt, Liliana Mura, Fabian Klein, Annette Frank, , Irmela Jeremias

The paper develops patient-derived AML PDX models that replicate primary AML biology and include subgroups lacking existing models, showing reduced leukemia growth after long-term chemotherapy.

bioRxiv · Sep 26, 2025 · PreprintCancer Biology

Pyjacker identifies enhancer hijacking events in acute myeloid leukemia including MNX1 activation via deletion 7q

Etienne Sollier, Anna Riedel, Umut H. Toprak, Justyna A. Wierzbińska, Dieter Weichenhan, Jan Philipp Schmid, Mariam Hakobyan, Aurore Touzart, Ekaterina Jahn, Binje Vick, Fiona Brown-Burke, Katherine A. Kelly, Simge Kelekçi, Anastasija Pejkovska, Ashish Goyal, , Christoph Plass

Pyjacker detects enhancer hijacking in AML, identifying MNX1 activation via 7q deletion as a novel oncogenic mechanism.

Blood Cancer Discovery · Mar 31, 2025Peer-reviewedCancer Biology

UHMK1 is a novel splicing regulatory kinase

Vanessa Cristina Arfelli, Yun-Chien Chang, Johannes Bagnoli, Paul Kerbs, Felipe E. Ciamponi, LAURA HELENA PAZ, Serhii Pankivskyi, Jean de Matha Salone, Alexandre Maucuer, Katlin B. Massirer, Wolfgang Enard, Bernhard Küster, Philipp A. Greif, Leticia Fröhlich Archangelo

This study identifies UHMK1 as a splicing regulatory kinase by showing its role in phosphorylation, alternative splicing, and cellular processes through integrated phosphoproteomics and RNA-seq analyses.

Journal of Biological Chemistry · Feb 17, 2023Peer-reviewedMolecular Biology