An optimized acetylcholine sensor for monitoring in vivo cholinergic activity
Miao Jing, Yuexuan Li, Jianzhi Zeng, Pengcheng Huang, Miguel Skirzewski, Ornela Kljakic, Wanling Peng, Tongrui Qian, Ke Tan, Jing Zou, Simon Trinh, Runlong Wu, Shichen Zhang, Sunlei Pan, Samuel Andrew Hires, , Yulong Li
The paper develops an optimized GRABACh sensor to measure in vivo cholinergic activity in Drosophila and mice, revealing compartmental ACh signals and single-trial dynamics.
Nature Methods · Sep 28, 2020Peer-reviewedNeuroscience