Samuel Andrew Hires

This study compares the firing patterns of pyramidal tract (PT) and intratelencephalic (IT) neurons in primary somatosensory cortex during whisker-guided object localization, finding differences in spike rates and encoding of touch-related information.

This study shows that acetylcholine dynamics in sensory cortex are driven by goal-directed motor actions rather than sensory cues or rewards during task learning.

This paper describes an automated homecage system for training mice in multiwhisker discrimination learning using air current stimulation and water reward, showing rapid learning and performance improvements.

The paper develops an optimized GRABACh sensor to measure in vivo cholinergic activity in Drosophila and mice, revealing compartmental ACh signals and single-trial dynamics.

The paper develops GRABNE sensors for rapid, specific in vivo detection of norepinephrine, demonstrating their use in various experimental contexts.