Author

Katherine S. Barker

St. Jude Children's Research HospitalORCID 0000-0002-3824-6829Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Christina A. CuomoiD· 3 shared Joachim MorschhäuseriD· 3 shared Jeffrey M. RybakiD· 2 shared Phillip David RogersiD· 2 shared Qing Hua ZhangiD· 2 shared Tracy L. PetersiD· 2 shared Darian J. SantanaiD· 1 shared David RogersiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMicrobiology

Christina A. CuomoORCID

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintMay 7, 2025

Mutations in transcription factors that confer fluconazole resistance also confer reduced susceptibility to manogepix in Candida auris, Candida albicans, Candida parapsilosis, and Candida glabrata (Nakaseomyces glabratus)

Katherine S. Barker, Hoja P. Patterson, Joachim Morschhäuser…·Phillip David Rogers

The paper identifies mutations in transcription factors that confer fluconazole resistance and also reduce susceptibility to manogepix in multiple Candida species.

DOI 10.1101/2025.05.07.652603

C. elegansbulk RNA-seq

𝕏 PostBluesky

MicrobiologybioRxivPreprintMar 31, 2025

Relative contributions of the ERG11VF125AL and MRR1AN647T mutations to fluconazole resistance in Clade III Candidozyma (Candida) auris clinical isolates

Katherine S. Barker, Qing Hua Zhang, Tracy L. Peters…·David Rogers

This study shows that the ERG11 mutation, not MRR1A, is primarily responsible for fluconazole resistance in Clade III C. auris isolates, while both mutations modestly affect voriconazole resistance but not other azoles.

2 citations

C. elegansgenetic perturbation / CRISPR

𝕏 PostBluesky

MicrobiologybioRxivPreprintFeb 11, 2025

Mutations in TAC1B drive CDR1 and MDR1 expression and azole resistance in C. auris

Katherine S. Barker, Darian J. Santana, Qing Hua Zhang…·Phillip David Rogers

This study shows that TAC1B mutations in C. auris increase fluconazole and triazole resistance by upregulating CDR1 and MDR1, with CDR1 being the main driver.

6 citations

C. elegansbulk RNA-seq

𝕏 PostBluesky