Joachim Morschhäuser

The paper identifies mutations in transcription factors that confer fluconazole resistance and also reduce susceptibility to manogepix in multiple Candida species.

This study shows that the ERG11 mutation, not MRR1A, is primarily responsible for fluconazole resistance in Clade III C. auris isolates, while both mutations modestly affect voriconazole resistance but not other azoles.

This study shows that TAC1B mutations in C. auris increase fluconazole and triazole resistance by upregulating CDR1 and MDR1, with CDR1 being the main driver.

This study shows that glucose uptake via GLUT1/3 is essential for neutrophil oxidative burst and lipid mediator production during microbial infection.