Broad-Spectrum Activity and Mechanisms of Action of SQ109 on a Variety of Fungi
Satish R. Malwal, Rocio Garcia‐Rubio, Milena Kordalewska, Hoja P. Patterson, Chi Zhang, Jorge D. Calderin, Ruijie Zhou, Akanksha M. Pandey, Erika Shor, David S. Perlin, Nathan P. Wiederhold, Luis Ostrosky‐Zeichner, Rutilio A. Fratti, Carol A. Nacy, Eric Oldfield
This study evaluates SQ109's antifungal activity against sixteen fungal pathogens and identifies its mechanisms involving mitochondrial targeting and isoprenoid biosynthesis pathway inhibition.
ACS Infectious Diseases · May 14, 2025Peer-reviewedMicrobiology