The paper introduces a deconvolution method to reconstruct properly sampled volumes from apparently undersampled oblique plane microscopy data, improving upon a previous Fourier-stitching approach.

bioRxiv · Apr 30, 2025 · PreprintBiophysics

Increasing the acquisition speed in oblique plane microscopy via Aliasing

Conor H. McFadden, James D. Manton, Holly Merta, Reto Paul Fiolka

This paper demonstrates that controlled aliasing in oblique plane microscopy can increase acquisition speed without loss of resolution or artifacts, enabling faster subcellular 3D imaging of mitochondrial dynamics.

Biomedical Optics Express · Mar 18, 2025Peer-reviewedBiophysics

navigate: an open-source platform for smart light-sheet microscopy.

Zach Marin, Xiaoding Wang, Dax W. Collison, Conor H. McFadden, Jinlong Lin, Hazel M. Borges, Bingying Chen, Dushyant Mehra, Qionghua Shen, Seweryn Gałecki, Stephan Daetwyler, Steven J. Sheppard, Phu Thien, Baylee A. Porter, Suzanne Daniela Conzen, , Kevin M. Dean

navigate provides an open-source platform for smart light-sheet microscopy, enabling automated and user-friendly LSFM workflows without requiring specialized expertise.

Nature Methods · Sep 11, 2024Peer-reviewedBiophysics

Adaptive Optics in an Oblique Plane Microscope

Conor H. McFadden, Zach Marin, Bingying Chen, Stephan Daetwyler, Xiaoding Wang, Divya Rajendran, Kevin M. Dean, Reto Paul Fiolka

This paper demonstrates adaptive optics in an oblique plane microscope, improving resolution and signal strength in zebrafish embryos.

Biomedical Optics Express · Jun 28, 2024Peer-reviewedCell Biology