Stephan Daetwyler

The paper introduces u-Segment3D, a tool that converts 2D cell segmentations into 3D consensus segmentations without training data, demonstrating effectiveness across diverse datasets.

The paper introduces miOPM, a reconfigurable LSFM platform that enables high-resolution imaging across multiple spatial scales and refractive indices.

The paper introduces a self-driving, multi-resolution light-sheet microscope to simultaneously observe sub-cellular dynamics and whole organisms over extended periods, applying it to study development, cancer, and immune interactions in zebrafish.

navigate provides an open-source platform for smart light-sheet microscopy, enabling automated and user-friendly LSFM workflows without requiring specialized expertise.

This paper demonstrates adaptive optics in an oblique plane microscope, improving resolution and signal strength in zebrafish embryos.

This study identifies BLTP2 as a pro-survival protein that regulates phosphatidylethanolamine levels in the plasma membrane to maintain its fluidity and function, linking it to cancer aggressiveness.

This study identifies Hand2 as a key regulator of mesothelium progenitors in zebrafish and shows its reactivation in mesothelioma, linking developmental processes to disease.

The paper describes the discovery of transient NO-containing spherical structures in zebrafish cerebral endothelial cells during development, showing their dependence on Notch signaling.

The paper presents a multi-sample imaging, processing, and analysis platform for studying vascular growth in zebrafish over time.

This study shows that basal extrusion drives tumor cell invasion and mechanical shedding of E-cadherin in zebrafish epidermis, with KRas mutations increasing invasion rates and p53 mutations enabling survival at distant sites.