Loss of host factor-mediated m6Am methylation of the viral RNA cap impairs SARS CoV-2 replication
Radha Raman Pandey, Nadine Ebert, David Homolka, G. Tuba Barut, Bettina Salome Trüeb, Hanspeter Stalder, Elena Delfino, Cathrine Broberg Vågbø, Inês Berenguer Veiga, Sebastian A. Leidel, Volker Thiel, Ramesh S. Pillai
This study identifies PCIF1 as a host factor that methylates the SARS-CoV-2 RNA cap, enhancing viral replication and reducing disease severity in mice.
bioRxiv · Apr 13, 2026 · PreprintMolecular Biology