Simone Pigolotti A

Ultrasensitive response in bacterial replication initiation

This study identifies the mechanisms of ultrasensitivity in bacterial replication initiation, showing it arises from DnaA dynamics under different growth conditions.

Single-molecule detection of transient dimerization of opioid receptors 2: Heterodimer blockage reduces morphine tolerance

The paper uses single-molecule imaging to study opioid receptor heterodimerization and shows that blocking MOR-DOR heterodimers reduces morphine tolerance in mice.

Single-molecule detection of transient dimerization of opioid receptors 1: Homodimers' effect on signaling and internalization

This study uses single-molecule imaging to show that opioid receptors form transient homodimers, with distinct functional effects on signaling and internalization depending on the receptor subtype.

Cell-cell communication as underlying principle governing color pattern formation in fishes

The paper identifies a gene involved in pigment cell communication that governs color pattern formation in zebrafish and anemonefish.

Amendable decisions in living systems

This paper characterizes the optimal strategy for amendable decisions in living systems and shows they can be made with zero error probability in finite time.

Hyperdisordered cell packing on a growing surface

The paper studies cell packing on a growing surface using squid skin chromatophores, finding hyperdisordered scaling and size distribution patterns.

Blocking uncertain mispriming errors of PCR

This paper demonstrates that a mixture of multiple blocker sequences can suppress PCR errors even with partial contaminating sequence information, improving the fidelity of PCR and related techniques.