Author

Stepan Jerabek

Czech Academy of Sciences, Institute of Organic Chemistry and BiochemistryORCID 0000-0002-3902-1939Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:gene regulatory network inference· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Diego MariniD· 2 shared Dieter M. EgliiD· 2 shared Jia L. XuiD· 2 shared Jimin Kim· 2 shared Nathan R. TreffiD· 2 shared Shuangyi XuiD· 2 shared Alex RoblesiD· 1 shared Anna‐Katerina HadjantonakisiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersDevelopmental Biology

Diego MarinORCID

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2 papers

Recent·Most cited

DNA Double Strand Breaks cause chromosome loss through sister chromatid tethering in human embryos

Jenna M. Turocy, Stepan Jerabek, Woonyung Hur, Jimin Kim, Shuangyi Xu, Qiaojin Zhao, Jia L. Xu, Alex Robles, Xiangyi Liu, Nathan R. Treff, Diego Marin, Anna‐Katerina Hadjantonakis, Dieter M. Egli

This study shows that DNA double-strand breaks in human embryos lead to chromosome loss through sister chromatid tethering and centromere-mediated separation.

Nature Communications · Jun 3, 2026Peer-reviewedDevelopmental Biology

Efficient base editing and development in human embryos without chromosomal alterations

Stepan Jerabek, Jimin Kim, Julie Sung, Chanju Jung, Marcos Iuri Roos Kulmann, Melisa Isado, Hong-Su Jang, Meng Li, Sakshi Bhatele, Michelle D. Kappy, Shuangyi Xu, Gue‐Ho Hwang, Jia L. Xu, Diego Marin, Jae‐Sung Woo, , Dieter M. Egli

This study shows that base editing in human embryos produces efficient on-target changes without chromosomal abnormalities or large deletions, unlike CRISPR/Cas9-induced DSBs.

bioRxiv · Jun 1, 2026 · PreprintGenetics