DNA Double Strand Breaks cause chromosome loss through sister chromatid tethering in human embryos
Jenna M. Turocy, Stepan Jerabek, Woonyung Hur, Jimin Kim, Shuangyi Xu, Qiaojin Zhao, Jia L. Xu, Alex Robles, Xiangyi Liu, Nathan R. Treff, Diego Marin, Anna‐Katerina Hadjantonakis, Dieter M. Egli
This study shows that DNA double-strand breaks in human embryos lead to chromosome loss through sister chromatid tethering and centromere-mediated separation.
Nature Communications · Jun 3, 2026Peer-reviewedDevelopmental Biology