Author

George Broutzakis

National and Kapodistrian University of AthensORCID 0000-0002-3902-4064Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:fungi (other)· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Christos GatsogiannisiD· 2 shared Alexander NeuhausiD· 1 shared Dierk NiessingiD· 1 shared Emmanuel MikrosiD· 1 shared Franz HagniD· 1 shared George DiallinasiD· 1 shared Ifigeneia AkraniiD· 1 shared Kai Fredriksson· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

Christos GatsogiannisORCID

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2 papers

Recent·Most cited

Structural basis of apoptosis induction by the mitochondrial voltage dependent anion channel

Melina Daniilidis, Umut Günsel, George Broutzakis, Kira D. Leitl, Robert Janowski, Kai Fredriksson, Dierk Niessing, Christos Gatsogiannis, Franz Hagn

This study reveals how VDAC1 oligomerization triggers apoptosis by exposing its N-terminal helix, which neutralizes anti-apoptotic BclxL and promotes pore formation by Bak.

Nature Communications · Oct 27, 2025Peer-reviewedBiophysics

High-resolution structures of the UapA purine transporter reveal unprecedented aspects of the elevator-type transport mechanism.

George Broutzakis, Yiannis Pyrris, Ifigeneia Akrani, Alexander Neuhaus, Emmanuel Mikros, George Diallinas, Christos Gatsogiannis

The paper reports cryo-EM structures of UapA, revealing the role of water, lipids, and the N-tail in its transport mechanism and subcellular trafficking.

bioRxiv · Aug 23, 2024 · PreprintBiophysics