Emmanuel Mikros

This study identifies cannabidiol and its semisynthetic analogues as potential synergists to enhance insecticide efficacy against pyrethroid-resistant malaria mosquitoes.

The paper reports cryo-EM structures of UapA, revealing the role of water, lipids, and the N-tail in its transport mechanism and subcellular trafficking.

This study reveals the transport mechanism of uracil/H+ by FurE, showing a step-wise, induced-fit process rather than the rocking-bundle mechanism.

This paper identifies lipid interactions critical for UapA dimerization and function, and shows how mutations can restore these interactions in a mammalian transporter.

The paper identifies motifs in the cytosolic termini of FurE that regulate endocytosis, pH-dependent gating, and substrate specificity through dynamic interactions.