George Diallinas

This study identifies the evolutionary origins of neurotransmitter synthesis and transport in fungi, showing these functions predate neurons and are linked to lysosomal processes in opisthokonts.

This study investigates the role of Ato proteins in carboxylic acid utilization in Candida albicans, revealing functional diversity and regulatory interactions among Ato family members.

This study identifies VapA as essential for polarized growth in Aspergillus nidulans by maintaining AP-2-mediated apical endocytosis and lipid domain organization.

The paper investigates distinct trafficking routes for polarized and non-polarized membrane proteins in Aspergillus nidulans, showing they use different secretory pathways and Golgi dependencies.

The paper reports cryo-EM structures of UapA, revealing the role of water, lipids, and the N-tail in its transport mechanism and subcellular trafficking.

The paper investigates the role of transmembrane segments 5 and 12 in the UapA transporter, showing how specific residues affect transport dynamics, substrate affinity, and specificity.

This study reveals the transport mechanism of uracil/H+ by FurE, showing a step-wise, induced-fit process rather than the rocking-bundle mechanism.

This paper identifies lipid interactions critical for UapA dimerization and function, and shows how mutations can restore these interactions in a mammalian transporter.

The paper identifies motifs in the cytosolic termini of FurE that regulate endocytosis, pH-dependent gating, and substrate specificity through dynamic interactions.