This study identifies a motor-sensory convergence point during object approach in rats, showing it enables robust object detection through dynamic sensory-motor interactions.

Journal of Neuroscience · Oct 26, 2026Peer-reviewedAnimal Behavior & Cognition

A bistable inhibitory OptoGPCR for multiplexed optogenetic control of neural circuits

Jonas Wietek, Adrianna Nozownik, Mauro Pulin, Inbar Saraf‐Sinik, Noa Matosevich, Raajaram Gowrishankar, Asaf Gat, Daniela Malan, Bobbie J. Brown, Julien Dine, Bibi Nusreen Imambocus, Rivka Levy, Kathrin Sauter, Anna Litvin, Noa Regev, , Ofer Yizhar

This paper identifies PdCO as a bistable GPCR with high temporal precision for optogenetic control of neural circuits in vivo.

Nature Methods · May 29, 2024Peer-reviewedNeuroscience

Optogenetic silencing of neurotransmitter release with a naturally occurring invertebrate rhodopsin

Mathias Mahn, Inbar Saraf‐Sinik, Pritish Patil, Mauro Pulin, Eyal Bitton, Nikolaos Karalis, Felicitas Bruentgens, Shaked Palgi, Asaf Gat, Julien Dine, Jonas Wietek, Ido Davidi, Rivka Levy, Anna Litvin, Fangmin Zhou, , Ofer Yizhar

This paper introduces eOPN3, a modified mosquito rhodopsin that suppresses synaptic transmission with high spatiotemporal precision in vivo.

bioRxiv · Feb 18, 2021 · PreprintNeuroscience