J. Simon Wiegert

This study shows that disrupting the brain-spleen axis accelerates disease progression in amyloidosis by impairing monocyte-microglia communication.

This study shows that CA3 input transiently modulates spatial coding in CA1 by inducing new place cells and shifting existing place fields without altering tuning or precision.

The paper examines the relationship between frontal cortical activity and pupil responses in mice during decision-making, finding that pupil-linked arousal tracks decision uncertainty and predicts future behavior adjustments.

This study investigates the interactions between serotonergic and noradrenergic systems in awake mice, revealing their combined and distinct roles in pupil-linked arousal.

The paper investigates how functional connectivity influences spine stability and spatial proximity in hippocampal neurons of awake mice.

This paper identifies PdCO as a bistable GPCR with high temporal precision for optogenetic control of neural circuits in vivo.

This study uses optogenetic manipulations to distinguish instructive from permissive roles of brain circuits in visual detection, showing that midbrain regions can compensate for primary visual cortex loss.

This paper introduces an optogenetic voltage-clamp technique for precise control of cellular voltage in live animals, demonstrating its application in C. elegans and rat neurons.

This paper introduces a flexible fiber photometry system that enables multicolor recording and optogenetic manipulation without complex hardware.

The paper introduces sDarken, a new family of genetically encoded serotonin sensors, demonstrating their effectiveness in imaging serotonin dynamics with high resolution.

The paper measures vesicular release probability at individual synapses and finds it determines synaptic strength rather than vesicle number or content.

The paper introduces Aion, a bistable anion-conducting channelrhodopsin with a long open state and precise light-switchable control, enabling extended neuronal silencing in Drosophila.

The paper uses optogenetic stimulation to induce spike-timing-dependent plasticity (STDP) and shows that late potentiation occurs regardless of spiking order, but requires ongoing activity.

The paper compares viral strategies for targeting locus coeruleus norepinephrine neurons, finding variability in transgene expression and no behavioral differences in cre-expressing mice.

The paper demonstrates polarization sensitivity in GPCR-based neurotransmitter sensors and introduces an optical device to mitigate orientation bias in two-photon imaging.

BiPOLES is an optogenetic tool that allows bidirectional control of neuronal activity using two different light colors, enabling both excitation and inhibition of the same neurons in a single experiment.

This study examines how different anesthetics affect hippocampal network activity, spine dynamics, and memory consolidation in mice, finding distinct impacts on neural function and memory.

This paper introduces eOPN3, a modified mosquito rhodopsin that suppresses synaptic transmission with high spatiotemporal precision in vivo.

The paper introduces SynTagMA, a tool to mark active synapses in a 2-second window, and provides software for analyzing large datasets of synaptic activity.

The paper shows that the sequence of plasticity-inducing events in hippocampal synapses affects their survival, with later protocols having a dominant effect.

The paper develops ultrafast glutamate sensors iGluu and iGluf to study high-frequency synaptic transmission, revealing presynaptic frequency-dependent filtering of spike trains.

The paper engineers anion-conducting channelrhodopsins with tunable spectra and kinetics for optogenetic control of behavior.