Radhika Basheer

Sustained Activation of a Defensive Behavior-Related Circuit Elicits a distinct Homeostatic Sleep Response

The paper compares homeostatic sleep responses after two types of wakefulness: gentle handling and optogenetic stimulation of defensive behavior-related neurons, finding distinct sleep recovery patterns.

Synaptic GABA dysfunction of thalamocortical neurons impairs sleep spindle morphology and fear extinction.

This study shows that synaptic GABAA receptor dysfunction in thalamocortical neurons disrupts sleep spindle morphology and impairs fear extinction in mice.

Photomapping the electrically coupled networks of the thalamus and cortex

This paper introduces opto-δL, a method to identify and quantify electrical synapses, and applies it to map coupled networks in thalamic and cortical tissues.

Neuronal PAS domain 1 identifies a major subpopulation of wakefulness-promoting GABAergic neurons in basal forebrain

This paper identifies Npas1+ neurons in the basal forebrain as a major GABAergic subpopulation involved in wakefulness and sleep regulation.

Sleep-Deep-Net learns sleep wake scoring from the end-user and completes each record in their style.

Sleep-Deep-Net automates sleep-wake scoring for rodent EEG/LFP data by learning from manual scores provided by users, achieving reliable results across various conditions and reducing manual scoring time to 1/12.

Characterization of basal forebrain glutamate neurons suggests a role in control of arousal and avoidance behavior

This study characterizes BF vGluT2 neurons, showing they project to arousal-related and aversive stimulus areas and induce avoidance behavior.

CRISPR knockdown of GABAA alpha3 subunits on thalamic reticular neurons enhances deep sleep

Basal forebrain parvalbumin neurons mediate arousals from sleep induced by hypercarbia or auditory stimuli

This study identifies BF parvalbumin neurons as a key component of the brain circuitry mediating brief arousals from sleep in response to internal and external stimuli.