Author

David S. Uygun

Harvard UniversityORCID 0000-0002-6592-3223Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:mouse· 8 Approach:experimental assay· 7 Research Focus:cell type annotation· 4 Assay:electronic health records· 4 Research Focus:differential expression· 2 Research Focus:spatial domain detection· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1

Frequent Co-Authors

Ritchie Edward BrowniD· 7 shared Fumi KatsukiiD· 6 shared Radhika BasheeriD· 6 shared James Timothy McKennaiD· 5 shared James M. McNallyiD· 4 shared Chun Zhi YangiD· 2 shared Tristan J. SprattiD· 2 shared Victoria Lombardi· 2 shared

Activity by Year

2020-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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7 shared papersNeuroscience

Ritchie Edward BrownORCID

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Author profile →

8 papers

Recent·Most cited

Sustained Activation of a Defensive Behavior-Related Circuit Elicits a distinct Homeostatic Sleep Response

Chun Yang, Victoria Lombardi, David S. Uygun, Ritchie Edward Brown, James Timothy McKenna, Radhika Basheer

The paper compares homeostatic sleep responses after two types of wakefulness: gentle handling and optogenetic stimulation of defensive behavior-related neurons, finding distinct sleep recovery patterns.

bioRxiv · Oct 12, 2026 · PreprintNeuroscience

Synaptic GABA dysfunction of thalamocortical neurons impairs sleep spindle morphology and fear extinction.

Fumi Katsuki, Meghan C Bauer, Mitchell J. Vaughn, Victoria Lombardi, Ritchie Edward Brown, Julie S. Haas, Radhika Basheer, David S. Uygun

This study shows that synaptic GABAA receptor dysfunction in thalamocortical neurons disrupts sleep spindle morphology and impairs fear extinction in mice.

bioRxiv · Sep 26, 2026 · PreprintNeuroscience

Early Loss of Deep Restorative Sleep and Auditory Stimulus Evoked 40-Hz activity of Hippocampal Parvalbumin Neurons in the APP/PS1 Mouse Model of Alzheimer's Disease

Fumi Katsuki, James M. McNally, Dmitry Gerashchenko, David S. Uygun, Alyssa Tyler, John G. McCoy, James Timothy McKenna, Ritchie Edward Brown

The paper identifies early loss of deep restorative sleep and 40-Hz activity in hippocampal PV neurons in APP/PS1 mice before cognitive deficits.

bioRxiv · Jul 1, 2026 · PreprintNeuroscience

Neuronal PAS domain 1 identifies a major subpopulation of wakefulness-promoting GABAergic neurons in basal forebrain

Timothy A. Troppoli, Chun Zhi Yang, Fumi Katsuki, David S. Uygun, Ilyan Lin, David D. Aguilar, Tristan J. Spratt, Radhika Basheer, James M. McNally, C. Savio Chan, James Timothy McKenna, Ritchie Edward Brown

This paper identifies Npas1+ neurons in the basal forebrain as a major GABAergic subpopulation involved in wakefulness and sleep regulation.

Proceedings of the National Academy of Sciences · May 15, 2024Peer-reviewedNeuroscience

Sleep-Deep-Net learns sleep wake scoring from the end-user and completes each record in their style.

Fumi Katsuki, Tristan J. Spratt, Ritchie Edward Brown, Radhika Basheer, David S. Uygun

Sleep-Deep-Net automates sleep-wake scoring for rodent EEG/LFP data by learning from manual scores provided by users, achieving reliable results across various conditions and reducing manual scoring time to 1/12.

bioRxiv · Dec 22, 2023 · PreprintNeuroscience

CRISPR knockdown of GABAA alpha3 subunits on thalamic reticular neurons enhances deep sleep

David S. Uygun, Chun Zhi Yang, Elena R. Tilli, Fumi Katsuki, James Timothy McKenna, James M. McNally, Ritchie Edward Brown, Radhika Basheer

bioRxiv · Dec 15, 2020 · PreprintNeuroscience

Basal forebrain parvalbumin neurons mediate arousals from sleep induced by hypercarbia or auditory stimuli

James Timothy McKenna, Stephen Thankachan, David S. Uygun, Charu Shukla, James M. McNally, Felipe L. Schiffino, Joshua Cordeira, Fumi Katsuki, Janneke C. Zant, Mackenzie C. Gamble, Karl A. Deisseroth, Robert W. McCarley, Ritchie Edward Brown, Robert E. Strecker, Radhika Basheer

This study identifies BF parvalbumin neurons as a key component of the brain circuitry mediating brief arousals from sleep in response to internal and external stimuli.

Current Biology · May 14, 2020Peer-reviewedNeuroscience

NREM consolidation and increased spindle counts improve age-related memory impairments and hippocampal representations

Robin K. Yuan, Matthew R. Lopez, Manuel-Miguel Ramos-Alavarez, Marc Eric Normandin, Arthur S. Thomas, David S. Uygun, Vanessa R. Cerda, Amandine E. Grenier, Matthew T. Wood, Celia M. Gagliardi, Herminio M. Guajardo, Isabel A. Muzzio

This study shows that acute sleep restriction improves memory and sleep quality in old mice but worsens these outcomes in young mice.

bioRxiv · Jan 20, 2020 · PreprintNeuroscience